Fwd: Smoking ban amendments pass at statehouse

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From: Live Search News: asbestos cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Smoking ban amendments pass at statehouse
To: mesothelioma77@gmail.com


Lincoln Journal Star - Sometimes, other situations such as bad luck, asbestos, and lead can lead to lung damage/cancer. Of course, those people would rather blame smokers. When this thing gets passed, many a small town bar is going to go under. Thanks, Nebraska ...

Wed, 13 Feb 2008 23:56:00 GMT

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Source: http://www.journalstar.com/articles/2008/02/15/news/politics/doc47b49cce8cd41343789296.txt
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Fwd: Psychology of exercise

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Psychology of exercise
To: mesothelioma77@gmail.com

Focus on your goals and you'll find yourself being regular. The final part of "Building a Foundation of Success". It is important to keep changing your routine and set new goals.

Sat, 16 Feb 2008 20:58:38 GMT

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Source: http://www.thehindu.com/mag/2008/02/17/stories/2008021750160600.htm
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Fwd: Meth Taking Pop-Culture Stage In Song, Television

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Meth Taking Pop-Culture Stage In Song, Television
To: mesothelioma77@gmail.com

Vince Gilligan needed a character who would do something truly despicable. So he turned to the ugliest thing he could think of: methamphetamine.

Thu, 14 Feb 2008 23:53:45 GMT

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Fwd: Fuzzy Math Leads to a (Serious) Reevaluation of Shipping's Climate Impact

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Fuzzy Math Leads to a (Serious) Reevaluation of Shipping's Climate Impact
To: mesothelioma77@gmail.com

Legodragonxp said: "I'm not knocking it, but I am curious about what kind of safety interlocking the system has Reevaluation of Shipping's Climate Impact by Jeremy Elton Jacquot, Los Angeles on 02.14.08 Image ...

Thu, 14 Feb 2008 23:56:13 GMT

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Source: http://www.treehugger.com/files/2008/02/shipping_emissions_climate_change.php
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Fw: Anxiety Disorders, National Mental Health Information Center

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From: CounsellingResource.com Search: mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Thursday, February 21, 2008 5:06:44 PM
Subject: Anxiety Disorders, National Mental Health Information Center

...Health Information Center. Contents What are anxiety disorders? Generalized Anxiety Disorder symptoms diagnosis treatment Panic Disorder symptoms diagnosis treatment Phobias symptoms diagnosis treatment Post-traumatic Stress...



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Fw: Rate of thromboembolic events in mesothelioma.

----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Saturday, February 23, 2008 10:57:15 PM
Subject: Rate of thromboembolic events in mesothelioma.

[1]Ann Thorac Surg. 2008 Mar; 85(3): 1032-8
Nguyen D, Lee SJ, Libby E, Verschraegen C

BACKGROUND: Thromboembolic event (TEE) rates in the general population and the cancer population are 0.1% to 2% and 10% to 15%, respectively. Our clinical observation is that mesothelioma patients are very susceptible to TEE, including arterial thromboses, but the TEE incidence has not been reported. This retrospective study attempts to determine the rates of TEE in patients with mesothelioma. METHODS: Three hundred seventy-four patients with mesothelioma were identified through the New Mexico SEER database. Sixty-five of them were included in the University of New Mexico tumor registry from 1973 to 2003. Documented TEE rates were abstracted from the patient charts. Chi-square test, Fisher's exact test, and logistic regression were used to identify potentially associated prognostic factors. RESULTS: Fifty-four medical records were reviewed. Patients had a median of six visits (range, 1 to 63 visits). Median age was 60 years (range, 29 to 79 years). Sex distribution was 11 women and 43 men. Anatomic locations of the primary tumor were 35 pleural, 17 peritoneal, 1 pericardial, and 1 pericardial or pleural mesothelioma. The TEE rate was 27.7% (15 of 54), including 10 deep venous thromboses, 2 arterial clots, 2 myocardial infarctions, and 1 pulmonary embolus. No association between the development of TEE and any known prognostic factors were observed. CONCLUSIONS: The 27.7% TEE incidence rate in mesothelioma patients is higher than in other cancer patients. The true incidence of TEE in mesothelioma is likely to be higher than the rate observed in our review, owing to the retrospective nature of the data. Prophylactic anticoagulation trials are recommended to determine the prevention benefit in this high-risk population.



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Fwd: Human Neuroblastoma Cells Rapidly Enter Cell Cycle Arrest and Apoptosis Following Exposure to C-28 derivatives of the Synthetic Triterpenoid CDDO.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Human Neuroblastoma Cells Rapidly Enter Cell Cycle Arrest and Apoptosis Following Exposure to C-28 derivatives of the Synthetic Triterpenoid CDDO.
To: mesothelioma77@gmail.com


[1]Cell Cycle. 2008 Feb 7; 7(5):
Alabran JL, Cheuk A, Liby K, Sporn M, Khan J, Letterio J, Leskov KS

Synthetic triterpenoids, such as 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and its derivatives, are an extremely potent class of new anti-cancer therapeutic agents, characterized by high antitumor potency and low toxicity to normal tissues. This report is the first to investigate the effects of C-28 derivatives of CDDO on 22 pediatric solid tumor cell lines, including neuroblastoma, rhabdomyosarcoma, osteosarcoma, and Ewing's sarcoma. We determined IC50s in the range of 5 - 170 nM for inhibition of colony formation and DNA synthesis, and 110 - 630 nM for metabolic cell death and decrease in cell number, using the C-28 CDDO analogs, CDDO methyl ester (CDDO-Me), CDDO imidazolide (CDDOIm), CDDO ethyl amide (CDDO-EA), CDDO trifluoroethyl amide (CDDO-TFEA), and CDDO diethylamide (CDDO-DE). After treatment of human neuroblastoma cells with CDDO-Me, cell cycle studies show depletion of the S-phase, while apoptosis studies show conformational activation and mitochondrial translocation of Bax protein, as well as activation of caspases -3 and -8. These data demonstrate the potential utility of CDDO analogs as promising novel therapeutic agents for high-risk pediatric solid tumors.



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Fwd: Meth, long the scourge of rural America, finally seeps into pop culture

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Meth, long the scourge of rural America, finally seeps into pop culture
To: mesothelioma77@gmail.com

So he turned to the ugliest thing he could think of: methamphetamine.The result is the new AMC series "Breaking Bad," where Gilligan's chemistry teacher protagonist, broke and dying of lung cancer, decides to ...

Fri, 15 Feb 2008 00:17:00 GMT

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Fwd: Should Doctors Advocate Alternative Sources of Nicotine?

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Should Doctors Advocate Alternative Sources of Nicotine?
To: mesothelioma77@gmail.com

Should doctors suggest alternative sources of nicotine to people who are unable to give up cigarettes, asks this week's BMJ? Smoking currently kills over 100,000 UK citizens each year, predominantly from lung ...

Fri, 15 Feb 2008 00:05:00 GMT

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Fwd: Each Cigarette You Take A Chance

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Each Cigarette You Take A Chance
To: mesothelioma77@gmail.com

Valentine's Day is Meant for lovers so maybe you're thinking about having a cigarette after a holiday snuggle.

Fri, 15 Feb 2008 01:14:21 GMT

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Fwd: Read the whole story

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From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Read the whole story
To: mesothelioma77@gmail.com

The Centers is Hiring! CFCC Is Hiring! '> Featured Jobs Hospice is Hiring Various Positions! The Centers is Hiring! CFCC Is Hiring! CFCC Is Hiring! The Centers is Hiring! Education links Being green In Jennifer ...

Fri, 15 Feb 2008 01:36:18 GMT

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Fw: [Pleural mesothelioma: impact of the staging for the therapeutic strategy]

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Saturday, February 23, 2008 5:09:57 AM
Subject: [Pleural mesothelioma: impact of the staging for the therapeutic strategy]

[1]Rev Mal Respir. 2007 Oct; 24(8 Pt 2): 6S146-56
Greillier L, Scherpereel A, Astoul P

Realistic improvement has been recently done for the treatment of malignant pleural mesothelioma. Besides new findings for the epidemiology of the disease, medico-social impact for patients, the knowledge of biological parameters for diagnosis, prognosis and future therapeutic targets as well, the early diagnosis of the disease mainly based on more extended practice of thoracoscopy allows in association with new imaging techniques a careful staging of the disease and consequently new therapeutic implications. Indeed if new balistic assessment of the disease improves the efficacy of radiotherapy and new combined chemotherapy have shown antitumoral responses, surgical strategy takes part in the armamenterium for this disease and combined with others therapeutic modalities seems to be a raisonnable approach despite the lack of prospective, comparative, randomized study and the drawback of current staging. However, the most important point is the multidisciplinary concertation induced by the management of this disease which represents a "model" in thoracic oncology.



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Fw: [Epidemiology, molecular biology, diagnostic and therapeutic strategy of malignant pleural mesothelioma in 2007 - an update]

----- Forwarded Message ----
From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Saturday, February 23, 2008 5:09:56 AM
Subject: [Epidemiology, molecular biology, diagnostic and therapeutic strategy of malignant pleural mesothelioma in 2007 - an update]

[1]Rev Mal Respir. 2007 Oct; 24(8 Pt 2): 6S157-64
Porret E, Madelaine J, Galateau-Sallé F, Bergot E, Zalcman G

Malignant pleural mesothelioma (MPM) is a rare tumour due to occupational asbestos exposure. The incidence of MPM will continue to increase until 2020-2030. The incidence reaches 100 cases/million/year in occupationally exposed populations as opposed to 1 case/million/year in the general population, leading to 800 to 1,000 cases per year in France. The molecular carcinogenesis of MPM is incompletely understood but alterations to genes NF2, c-met, WT1 RASSF and p16 have been described. These genes are involved in cell invasion and motility, cell division and apoptosis control. Histological diagnosis remains difficult and depends on immunohistochemical analysis as described by the French Mesopath group. Clinical diagnosis relies on thoracoscopy and large pleural biopsies, with increasing use of CT-PET for the evaluation of disease extent. Therapeutic strategy includes prophylactic irradiation following drainage or thoracoscopy to prevent tumour nodule development along drainage channels and puncture sites. In selected patients, extensive extra-pleural pneumonectomy can be performed with curative intent. First line chemotherapy is based on a combination of pemetrexed and cisplatin that has demonstrated an improvement in overall survival and quality of life in phase 3 trials. Antiangiogenic agents such as bevacizumab (Avastatin) may be of interest but need to be tested in phase 3 trials. The Mesothelioma Avastatin Pemetrexed Study (MAPS) is ongoing, coordinated by the French Thoracic Cancer Intergroup (IFCT).



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Fw: I-70 Driving Charge Open for Discussion (KKTV 11 Colorado Springs)

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From: Yahoo! News Search Results for dui insurance <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Saturday, February 23, 2008 10:48:56 PM
Subject: I-70 Driving Charge Open for Discussion (KKTV 11 Colorado Springs)

Senator Chris Romer has proposed charging people who drive on Interstate 70 during peak times as a way to ease weekend traffic.

Sat, 23 Feb 2008 17:55:17 GMT

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Fwd: Time to Remove the Subspecialty Blinders: Breast Cancer Does Not Exist in Isolation.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Time to Remove the Subspecialty Blinders: Breast Cancer Does Not Exist in Isolation.
To: mesothelioma77@gmail.com


[1]J Natl Cancer Inst. 2008 Feb 12;
Giordano SH, Hortobagyi GN





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Fwd: Nebraska's New Smoke-Free Law is Historic Win for Health

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Tue, Feb 26, 2008 at 10:26 PM
Subject: Nebraska's New Smoke-Free Law is Historic Win for Health
To: mesothelioma77@gmail.com

The following is a statement by William V. Corr, Executive Director, Campaign for Tobacco-Free Kids: All Nebraska workplaces, including restaurants, bars and gaming facilities, will be smoke-free beginning June ...

Tue, 26 Feb 2008 21:27:42 GMT

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Fwd: Bernie's battle: this time it's personal (Thursday Magnet)

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From: Yahoo! News Search Results for mesothelioma diagnosis <rssfwd@rssfwd.com>
Date: Mon, Feb 25, 2008 at 11:12 AM
Subject: Bernie's battle: this time it's personal (Thursday Magnet)
To: collegeschoolloan@gmail.com


Bernie Banton arrived in Canberra three weeks ago to fight the Federal Government. Now he is fighting for his life.

Mon, 25 Feb 2008 03:43:40 GMT

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Fwd: House Panel Rejects Last of Va. Anti-smoking Bills

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: House Panel Rejects Last of Va. Anti-smoking Bills
To: mesothelioma77@gmail.com

A last-gasp effort to ban smoking in restaurants and most other public places died Thursday in a House of Delegates subcommittee.

Fri, 15 Feb 2008 03:32:14 GMT

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=========================================================================

 

in another issue about cancer.... in particular about mesothelioma....

 

 

 The 2 surgical procedures used are pleurectomy with decortication and extrapleural pneumonectomy.

Surgical resection has been relied upon because radiation and chemotherapy get hold of been ineffective unequivocal treatments. There are now a number of cancer treatment options open to mesothelioma patients. Extrapleural pneumonectomy for selected victims with very early stage disease may expand recurrence-free survival, but the impact it has on overall survival is unknown at this time.

Mesothelioma diagnosis can be intimidating and can scare a lot of people, but mesothelioma diagnosis may give you a fighting chance if can be diagnose early. So do yourself a favor if you think that what you are suffering from and had worked in an asbestos related workplace.

The purpose of such investigations in mesothelioma diagnosis is to confirm and to determine the type of mesothelioma, to 'stage' the disease (measure how severe it is), and so to assess whether the disease is operable.

 

www.lingwellness.com

 

Fwd: A Novel Breast Tissue Density Classification Methodology.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: A Novel Breast Tissue Density Classification Methodology.
To: mesothelioma77@gmail.com


[1]IEEE Trans Inf Technol Biomed. 2008; 12(1): 55-65
Oliver A, Freixenet J, Mart R, Pont J, Perez E, Denton EE, Zwiggelaar R

It has been shown that the accuracy of mammographic abnormality detection methods is strongly dependent on the breast tissue characteristics, where a dense breast drastically reduces detection sensitivity. In addition, breast tissue density is widely accepted to be an important risk indicator for the development of breast cancer. Here, we describe the development of an automatic breast tissue classification methodology, which can be summarized in a number of distinct steps: 1) the segmentation of the breast area into fatty versus dense mammographic tissue; 2) the extraction of morphological and texture features from the segmented breast areas; and 3) the use of a Bayesian combination of a number of classifiers. The evaluation, based on a large kappa = 0.81 and 0.67 for the two data sets) between automatic and expert-based Breast Imaging Reporting and Data System mammographic density assessment.



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Fwd: High Pathologic Complete Response in HER 2-positive Locally Advanced Breast Cancer after Primary Systemic Chemotherapy with Weekly Docetaxel and Epirubicin.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: High Pathologic Complete Response in HER 2-positive Locally Advanced Breast Cancer after Primary Systemic Chemotherapy with Weekly Docetaxel and Epirubicin.
To: mesothelioma77@gmail.com


[1]Jpn J Clin Oncol. 2008 Feb 12;
Chen SC, Chang HK, Lin YC, Hsueh S, Cheung YC, Leung WM, Tsai CS, Lo YF, Tsai HP, Shen SC, Chen MF

BACKGROUND: To evaluate pathological complete response rate and to identify the predictor of response after primary systemic chemotherapy (PST) with weekly docetaxel and epirubicin for locally advanced breast cancer. METHODS: Sixty-three patients with locally advanced breast cancer received three cycles PST on day 1 and 8 of each 3-week cycle with epirubicin and docetaxel (epirubicin 45 mg/m(2) intravenous bolus, docetaxel 35 mg/m(2) in 100 ml normal saline infused 1 h), followed by surgery and adjuvant chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil. The pathological complete response was defined as no invasive carcinoma in breast and axillary nodes after PST. RESULTS: The median tumor sizes (by ultrasound) before and after PST were 6.2 and 2.5 cm, respectively. The negative estrogen receptor (ER) by immunochemical stain was found in 33 (52.4%) patients and HER-2/neu-overexperssion in 12 (19.0%) patients. Clinical overall response rate (ORR) was 89% (95% confidence intervals (95% CI: 81-97), including 38% complete response (95% CI: 26-50), sonographical ORR was 97% (95% CI: 93-100). The pathological complete response were found in 11 patients (18%, 95% CI: 9-27), and 15(24%, 95% CI: 13-35) patients achieved breast only pathological complete response. Nine (27.3%) of thirty-three ER (-) patients and 5 (41.7%) of 12 HER2-positive patients achieved pathological complete response. CONCLUSION: PST with weekly docetaxel and epirubicin were well-tolerated and very high pathological complete response rate was achieved in HER-2/neu -overexpression tumors.



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Fw: One Million for Meso

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From: Search for mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Thursday, February 21, 2008 5:06:45 PM
Subject: One Million for Meso

The Meso Foundation Allocates $1 Million for Research to Stop Asbestos Cancer SANTA BARBARA, Calif., Jan.

Thu, 10 Jan 2008 23:27:51 GMT

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Fwd: The short, appalling memory of politics

---------- Forwarded message ----------
From: Live Search News: asbestos cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: The short, appalling memory of politics
To: mesothelioma77@gmail.com


Sydney Morning Herald - ... the day before Bob Collins died in the early hours at his Darwin home after months of surgery and treatment for bowel cancer ... Bernie Banton, the anti-asbestos campaigner; and four former Labor MPs, including Collins. The other three: Queensland's Len ...

Sat, 16 Feb 2008 13:15:00 GMT

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Fwd: Cholesterol granuloma of the breast with unusual ossification features (osseous metaplasia).

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Cholesterol granuloma of the breast with unusual ossification features (osseous metaplasia).
To: mesothelioma77@gmail.com


[1]Pathol Res Pract. 2008 Feb 12;
Garofalo S, Casolino C, Accurso A, Falleti J

Cholesterol granuloma of the breast is a rare benign condition that can be mistaken for breast cancer. We present a case of a 42-year-old woman who presented with a 1-year history of asymptomatic palpable nodule in the upper external quadrant of the right breast. Mammography and ultrasonography suggested carcinoma, but excisional biopsy revealed cholesterol granuloma with unusual osseous metaplasia. Although reported to occur more frequently in the middle ear and mastoid process, we believe that better awareness of this rare benign condition is most important to avoid misdiagnosis and unnecessary surgery.



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Fwd: Risk Perceptions and Psychosocial Outcomes of Women With Ductal Carcinoma In Situ: Longitudinal Results From a Cohort Study.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Risk Perceptions and Psychosocial Outcomes of Women With Ductal Carcinoma In Situ: Longitudinal Results From a Cohort Study.
To: mesothelioma77@gmail.com


[1]J Natl Cancer Inst. 2008 Feb 12;
Partridge A, Adloff K, Blood E, Dees EC, Kaelin C, Golshan M, Ligibel J, de Moor JS, Weeks J, Emmons K, Winer E

Background Ductal carcinoma in situ (DCIS) has a generally favorable overall prognosis, with a systemic recurrence rate of approximately 1%, a local recurrence rate after mastectomy of 1%, and a local recurrence rate after breast-conserving treatment of less than 10%. Preliminary studies have suggested that women with DCIS may overestimate their risk of disease recurrence. Few data exist regarding psychosocial outcomes for women with DCIS. Methods Women in Eastern Massachusetts with newly diagnosed DCIS were asked to participate in a longitudinal study of risk perceptions, psychosocial concerns, and health behaviors. Psychosocial outcomes after DCIS diagnosis and risk perceptions were evaluated at enrollment and at 9 and 18 months. All statistical tests were two-sided. Results Four hundred eighty-seven women with DCIS (64% of eligible participants) completed the enrollment survey. Overall quality of life was good among the women surveyed, and the substantial anxiety at enrollment decreased with time (P

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Fwd: Comprehensive Analysis of DNA Repair Gene Variants and Risk of Meningioma.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Comprehensive Analysis of DNA Repair Gene Variants and Risk of Meningioma.
To: mesothelioma77@gmail.com


[1]J Natl Cancer Inst. 2008 Feb 12;
Bethke L, Murray A, Webb E, Schoemaker M, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Kosteljanetz M, Swerdlow A, Houlston R

Background Meningiomas account for up to 37% of all primary brain tumors. Genetic susceptibility to meningioma is well established, with the risk among relatives of meningioma patients being approximately threefold higher than that in the general population. A relationship between risk of meningioma and exposure to ionizing radiation is also well known and led us to examine whether variants in DNA repair genes contribute to disease susceptibility. Methods We analyzed 1127 tagging single-nucleotide polymorphisms (SNPs) that were selected to capture most of the common variation in 136 DNA repair genes in five case-control series (631 case patients and 637 control subjects) from four countries in Europe. We also analyzed 388 putative functional SNPs in these genes for their association with meningioma. All statistical tests were two-sided. Results The SNP rs4968451, which maps to intron 4 of the gene that encodes breast cancer susceptibility gene 1-interacting protein 1, was consistently associated with an increased risk of developing meningioma. Across the five studies, the association was highly statistically significant (trend odds ratio = 1.57, 95% confidence interval = 1.28 to 1.93; P(trend) = 8.95 x 10(-6); P = .009 after adjusting for multiple testing). Conclusions We have identified a novel association between rs4968451 and meningioma risk. Because approximately 28% of the European population are carriers of at-risk genotypes for rs4968451, the variant is likely to make a substantial contribution to the development of meningioma.



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Fwd: A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
To: mesothelioma77@gmail.com


[1]J Mol Med. 2008 Feb 13;
Verma NK, Dempsey E, Conroy J, Olwell P, McElligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y

The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, immune response, and development. A novel series of pyrrolo-1,5-benzoxazepines have been shown to potently induce apoptosis in variety of human chemotherapy resistant cancer cell lines, indicating their potential in the treatment of both solid tumors and tumors derived from the hemopoietic system. Pyrrolobenzoxazepine 4-acetoxy-5-(1-naphtyl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]-oxazepine (PBOX-15) has been shown to depolymerize tubulin in vitro and in the MCF7 breast cancer cell line. We hypothesized that this may suggest a role for this compound in modulating integrin-induced T-cell migration, which is largely dependent on the microtubule dynamics. Experiments were performed using human T lymphoma cell line Hut78 and peripheral blood T-lymphocytes isolated from healthy donors. We observed that human T-lymphocytes exposed to PBOX-15 have severely impaired ability to polarize and migrate in response to the triggering stimulus generated via cross-linking of integrin lymphocyte function associated antigen-1 receptor. Here, we show that PBOX-15 can dramatically impair microtubule network via destabilization of tubulin resulting in complete loss of the motile phenotype of T-cells. We demonstrate that PBOX-15 inhibitory mechanisms involve decreased tubulin polymerization and its post-translational modifications. Novel microtubule-targeting effects of PBOX-15 can possibly open new horizons in the treatment of overactive inflammatory conditions as well as cancer and cancer metastatic spreading.



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Fwd: Mayors welcome tagging crackdown

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Mayors welcome tagging crackdown
To: mesothelioma77@gmail.com

Auckland mayors have welcomed a proposed crackdown on tagging, but the National Party says government action has come too late.

Fri, 15 Feb 2008 02:38:46 GMT

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Fwd: External hypofractionated whole-breast radiotherapy: now where does accelerated partial breast irradiation stand?

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: External hypofractionated whole-breast radiotherapy: now where does accelerated partial breast irradiation stand?
To: mesothelioma77@gmail.com


[1]J Cancer Res Ther. 2007 Oct-Dec; 3(4): 231-5
Munshi A

Breast-conserving therapy (BCT) has emerged as a viable option for suitable breast cancer patients who are desirous of preserving the breast. The major advantage of BCT is the good cosmetic outcome with disease-free and overall survival similar to mastectomy. In this article, I have compared two emerging modalities for treating a preserved breast with radiotherapy. These two techniques in breast cancer - accelerated partial breast irradiation (APBI) and hypofractionated whole breast external beam radiotherapy - have their respective merits and drawbacks, and this article attempts to dissect the issue.



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Fwd: Robotic tumor-specific mesorectal excison of rectal cancer: short-term outcome of a pilot randomized trial.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: Robotic tumor-specific mesorectal excison of rectal cancer: short-term outcome of a pilot randomized trial.
To: mesothelioma77@gmail.com


[1]Surg Endosc. 2008 Feb 13;
Baik SH, Ko YT, Kang CM, Lee WJ, Kim NK, Sohn SK, Chi HS, Cho CH

BACKGROUND: Laparoscopic colorectal resection has become popular. The recently developed da Vinci Surgical System promises to facilitate endoscopic surgery and overcome its disadvantages. This study therefore aimed to compare the short-term results between robotic tumor-specific mesorectal excision (R-TSME) using the da Vinci Surgical System and conventional laparoscopic tumor-specific mesorectal excision (L-TSME) in rectal cancer patients. METHODS: Between April 2006 and February 2007, 36 patients were randomly assigned to receive R-TSME or L-TSME. During the study, 18 patients underwent robotic low anterior resection using the da Vinci Surgical System, and 18 patients had conventional laparoscopic low anterior resection. Patient characteristics, perioperative clinical results, complications, and pathologic details were compared between the two groups. RESULTS: The patient characteristics were not significantly different between the two groups. The mean operating time, hemoglobin change, and conversion rate were not significantly different between the groups. Complications were treated conservatively and did not require surgical intervention in the R-TSME group. The average length of stay was 6.9 +/- 1.3 days in the R-TSME group and 8.7 +/- 1.3 days in the L-TSME group (p

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Fwd: Large Colonic Lipoma Mimicking Colon Cancer and Causing Colonic Intussusception.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: Large Colonic Lipoma Mimicking Colon Cancer and Causing Colonic Intussusception.
To: mesothelioma77@gmail.com


[1]Dig Dis Sci. 2008 Feb 14;
Martin P, Sklow B, Adler DG





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Source: http://www.hubmed.org/display.cgi?uids=18270829
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Fwd: Cost-effectiveness of laparoscopy versus laparotomy for initial surgical evaluation and treatment of potentially resectable hepatic colorectal metastases: a decision analysis.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: Cost-effectiveness of laparoscopy versus laparotomy for initial surgical evaluation and treatment of potentially resectable hepatic colorectal metastases: a decision analysis.
To: mesothelioma77@gmail.com


[1]J Surg Oncol. 2008 Feb 12;
Karuna ST, Thirlby R, Biehl T, Veenstra D

BACKGROUND AND OBJECTIVES: Approximately 10-40% of colorectal cancer patients with potentially resectable hepatic metastases are incorrectly deemed resectable on standard pre-operative evaluation, including contrast-enhanced CT. Laparoscopy can identify unresectability in a majority of patients at highest risk of being incorrectly deemed resectable, sparing them an unnecessary laparotomy. However, laparoscopy requires an added investment by surgeons, patients, and payers. This analysis seeks to ascertain whether that investment is cost-effective. METHODS: A decision tree model was developed to evaluate the societal cost-effectiveness of laparoscopy versus laparotomy in colorectal cancer patients with hepatic metastases deemed resectable on standard pre-operative evaluation. This comparison involved the cost, the effectiveness, and the incremental cost-effectiveness (the cost in dollars for each quality-adjusted life-year saved) of each option. Sensitivity analysis was performed to evaluate the model's validity under a variety of assumptions. RESULTS: The cost-effectiveness of performing laparoscopy prior to laparotomy for resection of colorectal hepatic metastases depends primarily upon the probability of resectability determined at laparoscopy, and on the sensitivity of diagnostic laparoscopy. CONCLUSION: Laparoscopy for initial evaluation of resectability of hepatic metastases from colorectal cancer is most likely to benefit patients and save costs when performed after pre-operative risk stratification in patients at high risk of radiographically occult unresectable disease. J. Surg. Oncol. (c) 2008 Wiley-Liss, Inc.



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Source: http://www.hubmed.org/display.cgi?uids=18270972
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Fwd: Georgia Capitol Notes

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Sat, Feb 16, 2008 at 7:08 PM
Subject: Georgia Capitol Notes
To: mesothelioma77@gmail.com

HEADLINES Georgia Republicans' long-promised war on property taxes got underway at the state Capitol.

Sat, 16 Feb 2008 23:16:04 GMT

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Source: http://www.macon.com/220/story/269669.html
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Fwd: EnPro Industries Turns To Profit In Q4 [NPO]

---------- Forwarded message ----------
From: Live Search News: asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: EnPro Industries Turns To Profit In Q4 [NPO]
To: mesothelioma77@gmail.com


RTT News - ... quarter results, posting a turn in to a profit from loss in the year ago quarter, helped by a one-time gain and lower asbestos ... trial, CB7630 was administered orally, once daily, to chemotherapy-naïve patients with castration resistant prostate cancer ...

Thu, 14 Feb 2008 20:13:00 GMT

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Source: http://www.rttnews.com/sp/breakingnews.asp?date=02/14/2008&item=153
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Fwd: Vic anti-smoking groups lobbying for ban extension

---------- Forwarded message ----------
From: Search for lung cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Vic anti-smoking groups lobbying for ban extension
To: mesothelioma77@gmail.com

Anti-smoking groups say the new laws are working, and should be tightened even further There has been a victory in the battle against smoking, with new figures showing that young people are butting out in ...

Fri, 15 Feb 2008 03:57:03 GMT

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Source: http://www.abc.net.au/news/stories/2008/02/15/2163840.htm
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Fwd: Induction of ErbB-3 Expression by alpha6beta4 Integrin Contributes to Tamoxifen Resistance in ERbeta1-Negative Breast Carcinomas.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Induction of ErbB-3 Expression by alpha6beta4 Integrin Contributes to Tamoxifen Resistance in ERbeta1-Negative Breast Carcinomas.
To: mesothelioma77@gmail.com


[1]PLoS ONE. 2008; 3(2): e1592
Folgiero V, Avetrani P, Bon G, Di Carlo SE, Fabi A, Nisticò C, Vici P, Melucci E, Buglioni S, Perracchio L, Sperduti I, Rosanò L, Sacchi A, Mottolese M, Falcioni R

BACKGROUND: Tamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase in disease-free intervals of patients with positive hormonal receptors. However, the mechanisms involved in endocrine resistance are not clear. Laboratory and clinical data now indicate that bi-directional molecular cross-talk between nuclear or membrane ER and growth factor receptor pathways may be involved in endocrine resistance. We recently found a functional interaction between alpha6beta4 integrin and ErbB-3 receptor to maintain the PI3K/Akt survival pathway of mammary tumour cells. We sought to improve understanding of this process in order to provide the involvement of both receptors insight into mechanism of Tamoxifen resistance. METHODS AND FINDINGS: Using human breast cancer cell lines displaying different levels of alpha6beta4 and ErbB-3 receptors and a series of 232 breast cancer biopsies from patients submitted to adjuvant Tamoxifen monotherapy for five years, we evaluated the functional interaction between both receptors in relationship to Tamoxifen responsiveness. In mammary carcinoma cells, we evidenced that the alpha6beta4 integrin strongly influence Akt phosphorylation through ErbB-3 protein regulation. Moreover, the ErbB-3 inactivation inhibits Akt phosphorylation, induces apoptosis and inhibits in vitro invasion favouring Tamoxifen responsiveness. The analysis of human tumors revealed a significant relationship between alpha6beta4 and ErbB-3 in P-Akt-positive and ERbeta1-negative breast cancers derived from patients with lower disease free survival. CONCLUSIONS: We provided evidence that a strong relationship occurs between alpha6beta4 and ErbB-3 positivity in ERbeta1-negative breast cancers. We also found that the association between ErbB-3 and P-Akt positivity mainly occurs in ERbeta1-negative breast cancer derived from patients with lower DFS indicating that both receptors are clinically relevant in predicting the response to Tamoxifen.



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Fwd: Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRI.

---------- Forwarded message ----------
From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:07 PM
Subject: Breast tumor characteristics of BRCA1 and BRCA2 gene mutation carriers on MRI.
To: mesothelioma77@gmail.com


[1]Eur Radiol. 2008 Feb 13;
Veltman J, Mann R, Kok T, Obdeijn IM, Hoogerbrugge N, Blickman JG, Boetes C

The appearance of malignant lesions in BRCA1 and BRCA2 mutation carriers (BRCA-MCs) on mammography and magnetic resonance imaging (MRI) was evaluated. Thus, 29 BRCA-MCs with breast cancer were retrospectively evaluated and the results compared with an age, tumor size and tumor type matched control group of 29 sporadic breast cancer cases. Detection rates on both modalities were evaluated. Tumors were analyzed on morphology, density (mammography), enhancement pattern and kinetics (MRI). Overall detection was significantly better with MRI than with mammography (55/58 vs 44/57, P = 0.021). On mammography, lesions in the BRCA-MC group were significantly more described as rounded (12//19 vs 3/13, P = 0.036) and with sharp margins (9/19 vs 1/13, P = 0.024). On MRI lesions in the BRCA-MC group were significantly more described as rounded (16/27 vs 7/28, P = 0.010), with sharp margins (20/27 vs 7/28, P

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Source: http://www.hubmed.org/display.cgi?uids=18270717
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Fwd: Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
To: mesothelioma77@gmail.com


[1]Int J Cancer. 2008 Feb 12;
Calcagno SR, Li S, Colon M, Kreinest PA, Thompson EA, Fields AP, Murray NR

Oncogenic K-ras mutations are frequently observed in colon cancers and contribute to transformed growth. Oncogenic K-ras is detected in aberrant crypt foci (ACF), precancerous colonic lesions, demonstrating that acquisition of a K-ras mutation is an early event in colon carcinogenesis. Here, we investigate the role of oncogenic K-ras in neoplastic initiation and progression. Transgenic mice in which an oncogenic K-ras(G12D) allele is activated in the colonic epithelium by sporadic recombination (K-rasLA2 mice) develop spontaneous ACF that are morphologically indistinguishable from those induced by the colon carcinogen azoxymethane (AOM). Similar neoplastic changes involving the entire colon are induced in transgenic mice constitutively expressing K-ras(G12D) throughout the colon (LSL-K-ras(G12D)/Villin-Cre mice). However, the biochemistry and fate of K-ras-induced lesions differ depending upon their location within the colon in these mice. In the proximal colon, K-ras(G12D) induces increased expression of procarcinogenic protein kinase CbetaII (PKCbetaII), activation of the MEK/ERK signaling axis and increased epithelial cell proliferation. In contrast, in the distal colon, K-ras(G12D) inhibits expression of procarcinogenic PKCbetaII and induces apoptosis. Treatment of K-rasLA2 mice with AOM leads to neoplastic progression of small ACF to large, dysplastic microadenomas in the proximal, but not the distal colon. Thus, oncogenic K-ras functions differently in the proximal and distal colon of mice, inducing ACF capable of neoplastic progression in the proximal colon, and ACF with little or no potential for progression in the distal colon. Our data indicate that acquisition of a K-ras mutation is an initiating neoplastic event in proximal colon cancer development in mice. (c) 2008 Wiley-Liss, Inc.



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Fwd: Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy.
To: mesothelioma77@gmail.com


[1]Med Res Rev. 2008 Feb 12;
Zheng YG, Wu J, Chen Z, Goodman M

Epigenetics is concerned about heritable changes in gene expression without alteration of the coding sequence. Epigenetic modification of chromatin includes methylation of genomic DNA as well as post-translational modification of chromatin-associated proteins, in particular, histones. The spectrum of histone and non-histone modifications ranges from the addition of relatively small groups such as methyl, acetyl and phosphoryl groups to the attachment of larger moieties such as poly(ADP-ribose) and small proteins ubiquitin or small ubiquitin-like modifier (SUMO). The combinatorial nature of DNA methylation and histone modifications constitutes a significant pathway of epigenetic regulation and considerably extends the information potential of the genetic code. Chromatin modification has emerged as a new fundamental mechanism for gene transcriptional activity control associated with many cellular processes like proliferation, growth, and differentiation. Also it is increasingly recognized that epigenetic modifications constitute important regulatory mechanisms for the pathogenesis of malignant transformations. We review here the recent progress in the development of chemical inhibitors/activators that target different chromatin modifying enzymes. Such potent natural or synthetic modulators can be utilized to establish the quantitative contributions of epigenetic modifications in DNA regulated pathways including transcription, replication, recombination and repair, as well as provide leads for developing new cancer therapeutics. (c) 2008 Wiley Periodicals, Inc. Med Res Rev.



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Fwd: Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs.
To: mesothelioma77@gmail.com


[1]Med Res Rev. 2008 Feb 12;
Martinez A

The renewed interest in glycogen synthase kinase-3 (GSK-3), involved in the molecular pathogenesis of human severe diseases, is focused on the potential of its inhibitors to treat diseases that have significant limitations in their current treatments. During the last 5 years, a lot of literature discuss progress in the search and pharmacological actions of GSK-3 inhibitors, but now, evidence have been accumulated showing preclinical efficacy for these new drugs, in very different models of several distinct pathologies. These studies have been summarized in the present review offering promising examples for new therapies for diabetes, cancer, inflammation, Alzheimer's disease and other neurological pathologies, and mood disorders. Now, clinical human trials are awaiting to confirm the ray of hope that GSK-3 inhibitors are arising for the future treatment of severe unmet diseases. (c) 2008 Wiley Periodicals, Inc. Med Res Rev.



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Fwd: Radiology Degree Online - Sponsored Link

---------- Forwarded message ----------
From: Moreover Technologies - Top stories - of 854 returned <rssfwd@rssfwd.com>
Date: Fri, Feb 22, 2008 at 9:08 AM
Subject: Radiology Degree Online - Sponsored Link
To: collegeschoolloan@gmail.com


Ad - Explore degree options in Radiology/X-ray. Free online school info!

Fri, 22 Feb 2008 12:28:00 GMT

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Fwd: Anxiety Disorders, National Mental Health Information Center

 

---------- Forwarded message ----------
From: CounsellingResource.com Search: mesothelioma diagnosis <rssfwd@rssfwd.com>
Date: Thu, Feb 21, 2008 at 5:06 PM
Subject: Anxiety Disorders, National Mental Health Information Center
To: collegeschoolloan@gmail.com


...Health Information Center. Contents What are anxiety disorders? Generalized Anxiety Disorder symptoms diagnosis treatment Panic Disorder symptoms diagnosis treatment Phobias symptoms diagnosis treatment Post-traumatic Stress...



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Source: http://counsellingresource.com/distress/anxiety-disorders/anxiety-nmhic.html
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