Mesothelioma 23: Fwd: In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Thu, Apr 3, 2008 at 11:15 AM
Subject: In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms.
To: mesothelioma77@gmail.com

[1]Mol Nutr Food Res. 2008 Apr 1; 52(4): 447-456
Yu W, Jia L, Wang P, Lawson KA, Simmons-Menchaca M, Park SK, Sun L, Sanders BG, Kline K

The goal of these studies was to investigate the potential anticancer properties of two naturally occurring plant sources and two manufactured synthetic forms of vitamin E, i. e., RRR-alpha-tocopherol (alphaT), RRR-gamma-tocopherol (gammaT), all-rac-alpha-tocopherol (all-rac-alphaT), and all-rac-alpha-tocopheryl acetate (all-rac-alphaTAc) in breast cancer models. Vitamin E compounds were evaluated in vitro for inhibition of colony formation and induction of apoptosis in human MDA-MB-435 and MCF-7 breast cancer cells and murine 66cl-4 mammary cancer cells and in vivo for ability to reduce tumor growth and lung and lymph node metastases using the transplantable syngeneic BALB/c mouse 66cl-4-GFP mammary cancer model. gammaT inhibited colony formation and induced apoptosis in all three cancer cell lines. alphaT and all-rac-alphaT were less effective and all-rac-alphaTAc was ineffective. gammaT-induced apoptosis was correlated with activation of caspases-8 and -9 and down-regulation of protein expression of c-FLIP and survivin. In vivo study 1 analyses showed that all-rac-alphaT and all-rac-alphaTAc significantly inhibited tumor growth and inhibited both visible and microscopic size lung metastases. In vivo study 2 analyses showed that alphaT and gammaT reduced tumor growth, but only gammaT reduced tumor growth significantly in comparison to control. In conclusion, synthetic, but not natural, vitamin E exhibits promising anti-cancer properties in vivo.

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Source: http://www.hubmed.org/display.cgi?uids=18381678
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Thursday, April 3, 2008

Fwd: In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms.

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