From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Wed, Sep 24, 2008 at 1:30 PM
Subject: Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy.
To: mesothelioma77@gmail.com
[1]J Biol Inorg Chem. 2008 Sep 23;
Schmitt F, Govindaswamy P, Zava O, Süss-Fink G, Juillerat-Jeanneret L, Therrien B
Mononuclear 5-(4-pyridyl)-10,15,20-triphenylporphyrin and 5-(3-pyridyl)-10,15,20-triphenylporphyrin as well as tetranuclear 5,10,15,20-tetra(4-pyridyl)porphyrin (tetra-4-pp) and 5,10,15,20-tetra(3-pyridyl)porphyrin) (tetra-3-pp) arene ruthenium(II) derivatives (arene is C(6)H(5)Me or p-Pr( i )C(6)H(4)Me) were prepared and evaluated as potential dual photosensitizers and chemotherapeutics in human Me300 melanoma cells. In the absence of light, all tetranuclear complexes were cytotoxic (IC(50) /= 100 muM). Kinetic studies of tritiated thymidine and tritiated leucine incorporations in cells exposed to a low concentration (5 muM) of tetranuclear p-cymene derivatives demonstrated a rapid inhibition of DNA synthesis, while protein synthesis was inhibited only later, suggesting arene ruthenium-DNA interactions as the initial cytotoxic process. All complexes exhibited phototoxicities toward melanoma cells when exposed to laser light of 652 nm. At low concentration (5 muM), LD(50) of the mononuclear derivatives was between 5 and 10 J/cm(2), while for the tetranuclear derivatives LD(50) was approximately 2.5 J/cm(2) for the [Ru(4)(eta(6)-arene)(4)(tetra-4-pp)Cl(8)] complexes and less than 0.5 J/cm(2) for the [Ru(4)(eta(6)-arene)(4)(tetra-3-pp)Cl(8)] complexes. Examination of cells under a fluorescence microscope revealed the [Ru(4)(eta(6)-arene)(4)(tetra-4-pp)Cl(8)] complexes as cytoplasmic aggregates, whereas the [Ru(4)(eta(6)-arene)(4)(tetra-3-pp)Cl(8)] complexes were homogenously dispersed in the cytoplasm. Thus, these complexes present a dual synergistic effect with good properties of both the arene ruthenium chemotherapeutics and the porphyrin photosensitizer.
___
Source: http://www.hubmed.org/display.cgi?uids=18810507
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Just a Thought
Sleep soundly by protecting your most precious love ones and Family. This will be the most reassuring way of getting a good night sleep.
Have peace of mind. Life Insurance can protect your family and love ones financially.
Get Life Insurance Coverage and Enjoy Life With Humor and Funny Stuffs
The thing that one can do to relieve their stress and burden in life is to have some Humor and Funny Stuffs to watch and read. You can find these anywhere from your favorite online social utility networking site to any social sites that have humorous and funny stuffs. It is always important to have Life Insurance plan coverage to protect your love ones and your family too. Getting yourself insured is a relief in the sense that will not have to worry about the financial needs of your family and most dearest to your heart. To get started, you need to get some Life Insurance Quotes from amongst the Life Insurance Companies that are very stable and reliable.
Get the Best Info and guide on how to purchase Life Insurance and get some Life Insurance Quotes from a financially stable and sound Life Insurance Companies.
Make the best of what you can do Today because you don't know what is going to happen the next seconds, minute, hour or days and weeks. Enjoy life and what you have. Have peace of mind. Life Insurance can protect your family and love ones. Once you're covered make the best of what you have and what you can. Life is too short so to speak.
Sleep soundly by protecting your most precious love ones and Family. This will be the most reassuring way of getting a good night sleep.
Have peace of mind. Life Insurance can protect your family and love ones financially.
Get Life Insurance Coverage and Enjoy Life With Humor and Funny Stuffs
The thing that one can do to relieve their stress and burden in life is to have some Humor and Funny Stuffs to watch and read. You can find these anywhere from your favorite online social utility networking site to any social sites that have humorous and funny stuffs. It is always important to have Life Insurance plan coverage to protect your love ones and your family too. Getting yourself insured is a relief in the sense that will not have to worry about the financial needs of your family and most dearest to your heart. To get started, you need to get some Life Insurance Quotes from amongst the Life Insurance Companies that are very stable and reliable.
Get the Best Info and guide on how to purchase Life Insurance and get some Life Insurance Quotes from a financially stable and sound Life Insurance Companies.
Make the best of what you can do Today because you don't know what is going to happen the next seconds, minute, hour or days and weeks. Enjoy life and what you have. Have peace of mind. Life Insurance can protect your family and love ones. Once you're covered make the best of what you have and what you can. Life is too short so to speak.
Freshen Up Your Day. Watch and Upload Some of Your Humor and Funny Stuffs, Funny Videos At aseanface.com.
You will definitely enjoy and have fun with the humor and funny stuffs that aseanFace.com has to offer. You can also join the many who have signed up and uploaded their photos and pictures, upload their favourite videos, post on forums and post bulletins, post on their Blogs. Many posts on the Blogs are Humorous and funny Stuffs.
More Financial Info Links
Life Insurance, Term Life Insurance, Life Insurance Quotes, Life Insurance Companies, Life Insurance UK, Over 50s Life Insurance, Tesco Life Insurance UK, Life Insurance Quote, Cheap Life Insurance In UK, How Does Life Insurance Works, How Much Does Life Insurance Cost, What Is The Average Price Of Life Insurance , Statistics Disability Insurance, Calculate A Mortgage, Mortgage Calculator UK, Student Loans, Mortgage, Motor Insurance Gravesend, Understanding Automobile Insurance, Mortgage Refinance In Ontario Canada, Car Insurance, What Is The Average Price of Life Insurance, How Much Does Life Insurance Cost
More Links and Info Sites For Your Searches
Funny Tagalog Quotes, Funny Short Skits, Funny Car Commercials
I Need Some Funny Jokes Riddles For Teenagers, Really Funny Quick Jokes
Funny Goodbye Letters, Funny Rude Free Ecards, Funny Sick Twisted Humor
Funny Videos and Entertainment
aseanface.com , aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com, aseanface.com
Thanks very much,
Lorenz
I hope you like what we have posted here. Especially the links that we have provided for you searches and more information and guide on what is funny and humorous, you financial info needs and online social utility networking site that can help you keep in touch with friends, classmates, coworkers and people around them.
Have A Great Day and Enjoy Life