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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 7, 2008 at 3:45 AM
Subject: Structure-Activity Relationships in Cholapod Anion Carriers: Enhanced Transmembrane Chloride Transport through Substituent Tuning.
To: mesothelioma77@gmail.com
[1]Chemistry. 2008 Sep 4;
McNally BA, Koulov AV, Lambert TN, Smith BD, Joos JB, Sisson AL, Clare JP, Sgarlata V, Judd LW, Magro G, Davis AP
Chloride transport by a series of steroid-based "cholapod" receptors/carriers was studied in vesicles. The principal method involved preincorporation of the cholapods in the vesicle membranes, and the use of lucigenin fluorescence quenching to detect inward-transported Cl(-). The results showed a partial correlation between anion affinity and transport activity, in that changes at the steroidal 7 and 12 positions affected both properties in concert. However, changes at the steroidal 3-position yielded irregular effects. Among the new steroids investigated the bis-p-nitrophenylthiourea 3 showed unprecedented activity, giving measurable transport through membranes with a transporter/lipid ratio of 1:250 000 (an average of
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Source: http://www.hubmed.org/display.cgi?uids=18773409
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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 7, 2008 at 3:45 AM
Subject: Structure-Activity Relationships in Cholapod Anion Carriers: Enhanced Transmembrane Chloride Transport through Substituent Tuning.
To: mesothelioma77@gmail.com
[1]Chemistry. 2008 Sep 4;
McNally BA, Koulov AV, Lambert TN, Smith BD, Joos JB, Sisson AL, Clare JP, Sgarlata V, Judd LW, Magro G, Davis AP
Chloride transport by a series of steroid-based "cholapod" receptors/carriers was studied in vesicles. The principal method involved preincorporation of the cholapods in the vesicle membranes, and the use of lucigenin fluorescence quenching to detect inward-transported Cl(-). The results showed a partial correlation between anion affinity and transport activity, in that changes at the steroidal 7 and 12 positions affected both properties in concert. However, changes at the steroidal 3-position yielded irregular effects. Among the new steroids investigated the bis-p-nitrophenylthiourea 3 showed unprecedented activity, giving measurable transport through membranes with a transporter/lipid ratio of 1:250 000 (an average of
___
Source: http://www.hubmed.org/display.cgi?uids=18773409
--
~
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